Includes:
Ideal if: You already integrate technology and your team learns quickly.
Includes:
Ideal if: You want to standardize and communicate effectively from day one.
Includes:
Ideal if: You want a turnkey implementation.
Certified Medical Device
+4M satisfied patients
More than 50 clinical studies
+1000 clinics in over 30 countries
A tool supported by more than 15 published studies to address pain, sleep, stress, fatigue, overactive bladder and functional recovery through the autonomic nervous system.
Highlights published in indexed journals:
Results depend on patient profile, protocol and follow-up. NESA provides a measurable framework, not universal promises.
Yes. Very low-frequency microcurrents, imperceptible to the patient.
Depends on your starting point:
The XSIGNAL® device is the same in all options. What changes is the level of support, materials and implementation speed.
Investment depends on the selected structure and number of patient kits. There is no single published price because each proposal is adapted to volume, country and type of center.
What we can say:
Investment depends on the selected structure and number of patient kits. There is no single published price because each proposal is adapted to volume, country and type of center.
What we can say:
Investment depends on the selected structure and number of patient kits. There is no single published price because each proposal is adapted to volume, country and type of center.
What we can say:
Content intended for healthcare professionals.
NESA XSIGNAL® is a medical device and must be used according to its intended use, technical documentation, warnings, precautions and contraindications.
Indication, protocol selection, application frequency and follow-up are the responsibility of the healthcare professional.
This section is for informational and commercial purposes and does not replace official technical documentation or clinical judgment.
Low-frequency microcurrents applied at wrists and ankles. But the mechanism goes beyond nerve fibers. NESA XSIGNAL® interacts with the autonomic nervous system through two complementary pathways:
The signal travels through peripheral afferent nerve fibers to the brainstem (nucleus tractus solitarius), where it modulates sympathetic–parasympathetic balance. This pathway is validated in a clinical trial with carotid ultrasound (Mínguez-Esteban et al., Frontiers in Neuroscience, 2025).
Fascia is a continuous connective tissue network surrounding muscles, organs, nerves and blood vessels. Recent research shows fascia is not passive: it is a bioelectrically active regulatory system, densely innervated with sympathetic fibers and mechanoreceptors, acting as an interface between the musculoskeletal, endocrine and immune systems and the ANS.
Fascial collagen is piezoelectric: it generates electrical signals in response to mechanical stimuli. NESA microcurrents interact with this network, propagating signals beyond conventional neural pathways and reaching deeper structures through the extracellular matrix.
Slater et al. (Frontiers in Neurology, 2024) demonstrate that fascia contains neural elements closely connected to the ANS, acting as a “sentinel” that receives and processes information about the body’s global state.
Non-invasive peripheral stimulation
Surface electrodes placed at standardized points (wrists and ankles) deliver subsensory microcurrents (<<1 mA) during the session. The signal simultaneously reaches nerve endings and the fascial network of the surrounding connective tissue.
Dual activation: afferent pathways + bioelectrical fascial network
On one hand, the signal activates afferent nerve fibers that transmit information to the central nervous system. At the same time, the microcurrent interacts with the fascia—a continuous network of connective tissue rich in piezoelectric collagen, sympathetic fibers and mechanoreceptors (Ruffini, interstitial)—which propagates the bioelectrical signal to deeper structures. Stimulation of these fascial mechanoreceptors directly modulates sympathetic tone (Schleip, 2003; Stecco et al., 2022; Slater et al., Frontiers in Neurology, 2024).
Central autonomic modulation
The brainstem integrates signals from both pathways and readjusts the sympathetic–parasympathetic balance. The fascia acts as a modulatory interface between the musculoskeletal system, the immune system and the autonomic nervous system (Bordoni et al., American Journal of Physiology, 2024), amplifying the reach of neuromodulation beyond conventional neural pathways.
Measurable physiological response —
Double-blind ultrasound trial
The randomized, double-blind clinical trial by Mínguez-Esteban et al. (Frontiers in Neuroscience, 2025) demonstrated, through carotid ultrasound, immediate sonographic changes after just 20 minutes of treatment: increased carotid luminal diameter, reduced intima–media thickness and decreased heart rate. All measurable, all published, all reproducible. This vascular response confirms central autonomic modulation through both neural and fascial pathways.
Personal gloves, ankle bands and electrodes. Hygiene, traceability and consistent clinical experience. Single-patient use for safety.
1 set of gloves and ankle bands (sizes XS–XL, amputee version available)
1 bag of Ag/Cl ECG electrodes (50 units)
Storage bag
Electrode placement guide
Clinical reasoning sheet
Fichas de registro de paciente
Prepare the patient
Explain the process in 30 seconds and assign their personal kit.
Assess and record
Medical history + objective baseline assessment.
Define the starting point.
Design the plan
Select protocol or create a clinical reasoning plan based on comorbidities.
Program and apply
Program XSIGNAL® and apply according to Instructions for Use.
Passive or active therapy
Start a 30–60 minute session, optionally combined with other techniques.
Passive therapy (patient at rest) or active therapy (combined with exercise, manual therapy or other techniques).
