REBALANCE YOUR NERVOUS SYSTEM

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Discover non-invasive neuromodulation and your nearest clinic with NESA® medical technology.

Scientific and Actualización Científica y Académica

Scientific and Actualización Científica y Académica

5th APRIL

EOM Headquarters, Madrid

Trusted by over 30 leading international institutions

Scientifically validated technology, supported by clinical trials.

NESA XSIGNAL® NON-INVASIVE NEUROMODULATION

NESA is a non-invasive neuromodulation system based on an imperceptible surface treatment of electrical microcurrents generated by a device called XSIGNAL®.

These microcurrents are applied through low impedance areas of the skin to regulate the autonomic nervous system.

Clinically validated, it offers significant results in a wide variety of treatments, guaranteeing proven efficacy without adverse side effects.

HOW IT WORKS

The effect of NESA micro-electrical currents, applied by means of gloves and anklets, is multiplied by simultaneously stimulating 24 input pathways.

These structurally cover the entire body through four electrodes, one on each limb, and a fifth electrode called a directional electrode, which modulates the nervous system and pain, generating changes in neuronal electrical potentials and replicating specific patterns to optimise your body's homeostasis.

BENEFITS OF USING IT

By modulating your nervous system and promoting whole-body regulation, NESA safely and effectively optimises your physical and emotional well-being, giving you a sense of total balance.

It is the ideal choice for those looking to experiment:

  • Profound pain relief
  • Calming the mind
  • Recovering active energy
  • Improving health and longevity
  • Faster post-surgical recovery
  • Significant improvement in the quality of your sleep
  • And much more…

Watch 1,000+ YouTube testimonials on our effectiveness.

Leading healthcare professionals in rehabilitation, neurology, mental health, urogynecology and traumatology rely on NESA® medical technology to transform the lives of their patients.

NESA® MICROCURRENTS: Redefining standards in medical treatment.

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Our Story: Innovation and Commitment to Health

A Legacy that Transcends Borders

More than 50 years ago in Japan, the NESA® non-invasive neuromodulation technology was created. What began in 1987 with a prototype featuring 192 electrodes has evolved into a benchmark in neuromodulation, improving the lives of millions of people around the world.

At NESA WORLD®, we continue to refine this technology, collaborating with universities and clinics to expand its applications and push its impact to new frontiers.

REFERENCES PAPERS

  1. García F, Fernández D, Vázquez-Guerrero J, et al. (2022) Recovery of the physiological status in professional basketball players using NESA neuromodulation treatment during different types of microcycles in season: A preliminary randomized clinical trial.Frontiers in Physiology. 2022;13.https://www.frontiersin.org/articles/10.3389/fphys.2022.1032020
  2. Medina-Ramírez, R., Molina-Cedrés, F., Báez-Suárez, A., & Álamo-Arce, D. (2021). Nesa Non-Invasive Neuromodulation; A New Frontier of Treatment of the Autonomous Nervous System in Physiotherapy. 4.DOI: https://www.cientperiodique.com/article/CPQOS/5/4/97

  3. Teruel-Hernández, E., López-Pina, J. A., Souto-Camba, S., Báez-Suárez, A., Medina-Ramírez, R., & Gómez-Conesa, A. (2023). Improving sleep quality, daytime sleepiness, and cognitive function in patients with dementia by therapeutic exercise and NESA neuromodulation: A multicenter clinical trial. International Journal of Environmental Research and Public Health, 20(21), 7027. https://doi.org/10.3390/ijerph20217027

  4. Báez-Suárez, A., Padrón-Rodríguez, I., Castellano-Moreno, E., González-González, E., Quintana-Montesdeoca, M. P., & Medina-Ramirez, R. I. (2023). Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation. BMC Pediatrics, 23(1), 465. https://doi.org/10.1186/s12887-023-04307-4

  5. Contreras, M., Medina-Ramírez, R., Teruel-Hernandez, E., Vilchez-Barrera, M., Báez-Suárez, A., & Álamo Arce, David. (2023). Rehabilitation in Sleep, Pain, and Bladder Symptoms of NESA Neuromodulation Application in Multiple Sclerosis Patients: A Innovative Treatment. CPQ Medicine Journal, 15(1). https://www.cientperiodique.com/article/CPQME-15-1-439.pdf
  6. Medina-Ramírez, R., Mallol Soler, M., García, F., Pla, F., Báez-Suárez, A., Teruel Hernández, E., Álamo-Arce, D. D., & Quintana-Montesdeoca, M. d. P. (2024). Effects in sleep and recovery processes of NESA neuromodulation technique application in young professional basketball players: A preliminary study. Stresses, 4(2), 238-250. https://doi.org/10.3390/stresses4020014

  7. Bonilla-Eizaguirre, M., Martín, M., Hernández-Pérez, A., Vílchez-Barrera, M., Medina-Ramírez, R., & Báez-Suárez, A. (2024). Efficacy of NESA non-invasive neuromodulation in patients with post-traumatic cervicalgia. International Journal of Research and Scientific Innovation (IJRSI), 11(10), 474. https://doi.org/10.51244/IJRSI

  8. Vega-Delgado, N., García-Rodríguez, I., Saldanha, L., Báez-Suárez, A., Vílchez-Barrera, M., Álamo-Arce, D., Hernández-Pérez, A., & Medina-Ramírez, R. (2024). New frontier in sleep disorders: The rising of an innovative non-invasive neuromodulation treatment. International Journal of Research and Scientific Innovation (IJRSI), 11(15), 49. https://doi.org/10.51244/IJRSI.2024.11150049P

  9. Báez-Suárez, A., Báez-Suárez, V., Saldanha, L., Vílchez-Barrera, M., Hernández-Pérez, A., & Medina-Ramírez, R. (2025). Improving Sleep Quality and Well-Being in Institutionalized Older Adults: The Potential of NESA Non-Invasive Neuromodulation Treatment. Geriatrics, 10(1), 4. https://doi.org/10.3390/geriatrics10010004

  10. VASCULAR Front. Physiol Acute sonographic changes in common carotid artery after NESA neuromodulation intervention in healthy adults: a randomized controlled clinical trial doi: 10.3389/fphys.2025.1526236
    https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1526236/abstract

  11. PAIN Azevedo, N., & Medina-Ramírez, R. (2025). Pain and the autonomic nervous system: The role of non-invasive neuromodulation with NESA microcurrents. Frontiers in Pain Research, 6, Article 1410808. https://doi.org/10.3389/fpain.2025.1410808

CONFERENCES

  1. Molina, F., Medina-Ramírez, R., Báez, A. Álamo-Arce, DD. (2020). Recuperación exitosa de un Síndrome Regional Complejo a través de la electroterapia de neuromodulación del Sistema Nervioso Autónomo. 58o Congreso SERMEF. Mallorca, España.http://hdl.handle.net/10553/114084

  2. Medina-Ramírez. (2021). ¿Los deportistas profesionales tienen una óptima calidad del sueño?Aprender a dormir, una asignatura pendiente. XXIX Reunión Anual de la Sociedad Española del Sueño, España.

  3. Medina-Ramírez, RI., Molina, F., Medina-Ramírez, R., Báez, A. Álamo-Arce. Tecnología NESA. Un nuevo tratamiento revolucionario en fisioterapia. Macaronesian Researcher`s night. In Horizonte 2020 Congress. 2020. Las Palmas, Spain.

  4. Lledó-Amat, M., Medina-Ramírez, R., Álamo-Arce, & Arteaga-Ortiz, R. (2021). Efectos de la Neuromodulación no invasiva NESA en el tratamiento de secuelas de Ictus: A propósito de un caso. Congreso Nacional de Fisioterapia de la UMH, España.

  5. Lledó-Amat, M., ancho-Francés, A., Medina-Ramírez, & Álamo-Arce, D. (2021). Tratamiento de la neuralgia del trigémino con Neuromodulación no invasiva NESA: A propósito de un caso. Congreso Nacional de Fisioterapia de la UMH, España.

  6. Medina-Ramírez, R., & Roman, T. (2021). Efectos de la Neuromodulación no invasiva NESA en el tono muscular, el dolor y el sueño, en pacientes bruxistas.Aprender a dormir, una asignatura pendiente. XXI reunión Anual de la Sociedad Española del Sueño, España.

  7. Contreras, M., & Medina-Ramírez, R. I. (2021). Caso clínico de neuromodulación superficial aplicada (NESA) en pacientes con Esclerosis Múltiple. Congreso de fisioterapia nacional UMH, España

  8. Medina-Ramírez, R., Molina-Cedrés, F., & Moreno, A. (2022). Potenciando la fisioterapia invasiva a través del sistema nervioso autónomo. I JORNADA PRESENCIAL Fisioterapia invasiva. Barceona, Spain.

  9. Cano-Uceda, A. Aparicio-Montero, P. Medina-ramírez, R. (2023) Effectiveness of non-invasive neuromodulation in improving sleep quality and stress in physiotherapy students. Multicenter study. In SPRM Congress 2023. Colombia.

  10. Molina-Cedrés, F., González, M., & Medina-Ramírez, R. (2022). Combining physiotherapy techniques: Treatment of plantar fasciitis with NESA neuromodulation and electrolysis. The International Society for Physical Rehabilitation Medicine Conference. The International Society for Physical Rehabilitation Medicine, Lisbon, Portugal.

  11. Contreras, M., Medina-Ramírez, R., & Molina-Cedrés. (2022). Nesa Non-invasive neuromodulation; a chance to approach Sclerosis Multiple symptoms. The International Society for Physical Rehabilitation Medicine Conference. The International Society for Physical Rehabilitation Medicine, Lisbon, Portugal.

  12. Báez-Suárez, A., Medina-Ramírez, R., Molina-Cedrés, Padrón, I., Montesdeoca, M. del P., Castellano, E., & González, E. (2022). Can microcurrents help children with neurodevelopmental disorders with their defecation and sleep quality problems? The International Society for Physical Rehabilitation Medicine Conference. The International Society for Physical Rehabilitation Medicine, Lisbon, Portugal.

  13. Ruíz-lópez, K., González, M., & Medina-Ramírez, R. (2023). NESA Neuromodulation in pelvic floor and uroginecology. I NESAevent Internacional Conference. I NESAevent Internacional Conference, Madrid, Spain.

  14. Medina-Ramírez, R., Molina-Cedrés, F., Báez-Suárez, A., Álamo Arce, D., & Mallol-Soler, M. (2022). Improving sleep quality: The new frontier of physical therapy neuromodulation of the autonomic nervous system. Congreso Internacional de Fisioterapia de Cataluña. Congreso Internacional de Fisioterapia de Cataluña, Barcelona, Spain.

  15. Báez-Suárez, A., Pestana-Miranda,R. Álamo-Arce, D. Martín-Castillo, E., Medina-Ramírez, R.(2020). Effectiveness of non-invasive neuromodulation in children with neurodevelopmental disorders to improve constipation and sleep quality. In SPRM Congress. Belgrade, Serbia.

  16. Zamorano, E., & Medina-Ramírez, R. (2022). Face to Face. Neuromodulación percutánea versus no invasiva (sistemas inductivos de alta intensidad y NESA). V Congreso Internacional de Fisioterapia Invasiva. V Congreso Internacional de Fisioterapia Invasiva, Madrid, Spain.

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