RESEARCH AND DEVELOPMENT

Scientific basis of NESA® technology

Scientific advances achieved through international collaboration in bioelectricity and the autonomic nervous system.

At NESA WORLD®, we advance scientific progress through strategic partnerships with universities, hospitals, and research centres.

With experience from over 30 congresses and 15 international conventions, we advance the clinical use of non-invasive neuromodulation to enhance the nervous system’s natural responses in healthcare.

Results

Quality of life

Sleep quality

Increase in REM phase

Increase in the number of hours of sleep

Maintenance of sleep quality

Improvement in daytime sleepiness

Reduction in pain perception

Reduction in episodes of urinary incontinence

Improvement in cognitive function

Improvement in constipation

Improvement in the type of defecation

Improvement in the prevalence of intestinal problems

These results reflect observations in specific study populations; the effects may vary for each individual.

The mechanisms of non-invasive NESA® neuromodulation.

NESA® technology is based on the delivery of patented low-frequency microcurrents to the nerve pathways of the peripheral autonomic nervous system, affecting the vagus nerve and the central nervous system to achieve global and comprehensive neuromodulation, with clinical trials showing:

Overall well-being
+66% in perceived quality of life

Main Scientific Results

Improved Quality of Life

Studies have used quality of life as a key indicator to assess the effects of NESA® microcurrent therapy.

66% improvement in EuroQol-5D scores compared to the placebo group.

Clinical Impact:

Significant reduction in anxiety, pain and discomfort.

Improved ability to perform daily activities, mobility and self-care.

Results with the CACV Questionnaire:

Placebo group: slight improvement attributed to the placebo effect (no significant difference).

NESA® Group: rapid and sustained changes throughout treatment.

Reference:

Conde-Santos, G., Martín-Martínez, A., Carballo-Rastrilla, S., Fernández-Mederos, A., Báez-Suárez, A., Hernández-Pérez, A., Quintana Montesdeoca, M. P., Medina-Ramírez, R. “Efficacy of the autonomic nervous system approach using NESA neuromodulation for the treatment of overactive bladder: A randomised trial”. 2024.

Sleep quality
+40% in subjective sleep perception

Main Scientific Results:

Comparison of sleep quality between groups

Use of the Pittsburgh Sleep Quality Index (PSQI).

Significant differences after 5 months (p = 0.048) and 7 months (p = 0.002).

Improvement in the NNG and TEG groups, with a reduction in PSQI scores.

The NNG group showed the best evolution.

The CG group experienced a worsening of sleep quality.

PRE and POST results:

Significant differences between PRE and POST assessments (p = 0.002).

Decrease of 4 points in the final PSQI score.

Impact of NESA neuromodulation:

NESA microcurrents demonstrated a significant improvement in sleep quality.

Users experienced an improvement in the quality of their night's sleep.

Sleep quality studies with NESA:

Assessment in various pathological contexts and age groups.

Use of the PSQI to assess patients' subjective perception of their sleep quality.

Perceived improvement in sleep quality between 30% and 50%, depending on the protocol and the specific characteristics of the population studied.

Reference:

Teruel-Hernández E, López-Pina JA, Souto-Camba S, Báez-Suárez A, Medina-Ramírez R, Gómez-Conesa A. Improving Sleep Quality, Daytime Sleepiness, and Cognitive Function in Patients with Dementia by Therapeutic Exercise and NESA Neuromodulation: A Multicenter Clinical Trial. International Journal of Environmental Research and Public Health. 2023; 20(21):7027.

REM sleep phase
+20% in duration

Main Scientific Results:

Significant improvement: NESA neuromodulation improves REM sleep, essential for cognitive and emotional recovery.
Evidence: Actigraphy showed a 20% increase in REM phase in patients with stress and anxiety, suggesting stabilisation of the autonomic nervous system.
Positive effects: Improved rest and long-term benefits in emotional regulation and cognitive performance, especially in sleep disorders and stress.

Comparison with placebo:

NESA group: Longer time in REM phase (8.54 min vs. 7.11 min, p = 0.007).
Significant differences: Most noticeable in weeks 4 and 6, coinciding with the start of the playoffs.

Reference:

Medina-Ramírez R, Mallol Soler M, García F, Pla F, Báez-Suárez A, Teruel Hernández E, Álamo-Arce DD, Quintana-Montesdeoca MdP. Effects in Sleep and Recovery Processes of NESA Neuromodulation Technique Application in Young Professional Basketball Players: A Preliminary Study. Stresses. 2024; 4(2):238-250.

Total sleep time
+30% in hours of rest

Main Scientific Results:

Increase in the number of hours of sleep:

30% increase in total sleep duration.

Significant improvement in the quality of rest of patients with high levels of stress and anxiety.

Measured objectively by actigraphy.

The treatment helps to regulate the autonomic nervous system, facilitating the reconciliation and maintenance of sleep.

Long-term benefits:

More complete physical and mental recovery.

Improved emotional resilience, cognitive function and general health.

Therapeutic value of NESA neuromodulation in the management of sleep disorders.

Progression of sleeping hours during treatment:

The hours of sleep increased progressively as the treatment progressed.

The positive effects were maintained two weeks after the intervention.

Reduction of sleep interruptions:

Initial average of 3.83 interruptions during the baseline phase.

Decrease to 1.17 interruptions in the fourth week of intervention.

It stabilised at 1.61 interruptions two weeks after the intervention.

Reference:

Báez-Suárez, A., Padrón-Rodríguez, I., Castellano-Moreno, E., González-González, E., Quintana-Montesdeoca, M. P., & Medina-Ramirez, R. I. (2023). Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation. BMC Pediatrics, 23(1), 465.

García F, Fernández D, Vázquez-Guerrero J, et al. (2022) Recovery of the physiological status in professional basketball players using NESA neuromodulation treatment during different types of microcycles in season: A preliminary randomized clinical trial. Frontiers in Physiology.

Daytime sleepiness
-60% in daytime fatigue and tiredness

Main Scientific Results:

Reduction of daytime fatigue:

60% reduction in feelings of tiredness and daytime sleepiness in people with high levels of stress and anxiety.
Optimisation of the autonomic nervous system through NESA neuromodulation.
Improves the quantity and quality of rest, promoting a deeper and more restful sleep.

Additional benefits:

Significant reduction in daytime fatigue, improving concentration, emotional stability and cognitive performance.
It facilitates complete physical and mental recovery, highlighting NESA's therapeutic potential in stress-related sleep disorders.

Evolution of daytime sleepiness:

NESA treatment showed statistically significant differences in the evolution of daytime sleepiness (p < 0.05) at all measurement points.
This indicates that NESA microcurrents contribute to the improvement of daytime sleepiness throughout the treatment.

Reference:

Urinary urgency
−60% in episodes among patients with voiding dysfunction

Main Scientific Results:

Reduction of urinary urgency:

60% reduction in urinary urgency episodes through NESA neuromodulation.
Use of electrical microcurrents to stimulate the nervous system and treat overactive bladder.
Decreased frequency of incontinence episodes and improved overall quality of life.

Benefits for patients:

Less disruption to daily activities and reduced emotional stress.
Improvement of general well-being and contribution to better sleep quality.
Relief of other secondary symptoms, reinforcing the therapeutic efficacy of NESA in the management of urinary incontinence.

Statistical results:

Statistically significant reduction in the number of daily micturitions in the NESA-treated group (P < 0.05).
The placebo group showed initial improvement, but symptoms returned to baseline levels or worsened, suggesting that the improvement was not sustained.

Reference:

Chronic constipation
−47% in symptom frequency

Main Scientific Results:

Efficacy in reducing chronic constipation:

47% improvement in the reduction of chronic constipation with NESA neuromodulation.

Stimulation of the autonomic nervous system to promote intestinal motility and improve digestive function.

Impact on intestinal motility:

Restoration of neurophysiological balance, promoting regular bowel movements.

Relief of constipation symptoms and improvement of gastrointestinal well-being.

Defecation frequency results:

Reduction from 87% of participants with less than 3 bowel movements per week to 8.7% after the intervention.

60.9% of participants achieved a frequency of 3-6 bowel movements per week.
30.4% experienced daily bowel movements.

Reference:

Bowel function
+58% in stool quality

Main Scientific Results:

Improvement in the type of defecation:

58% improvement in defecation type according to the Bristol scale with NESA neuromodulation.

Regulation of the autonomic nervous system facilitating more regular and efficient bowel movements.

Impact on stool consistency and frequency:

Restoration of neurophysiological balance, improving stool consistency and frequency.

Contributes to a healthier and more comfortable defecation experience.

Outcomes in participating children:

69% of children initially had hard stools (Type 1-2); 87.5% improved to normal stools (Type 3-5) after the intervention.

All children with liquid stools (Type 6-7) achieved normal stools after the intervention, and the improvement was maintained up to two weeks later.

Reference:

Chronic pain
−60% in perceived persistent pain

Main Scientific Results:

Reduction of chronic pain with NESA microcurrents:

Up to 60% reduction in the intensity of chronic pain by stimulating specific areas of the nervous system.

Mechanisms of action contributing to pain reduction:

Modulation of neuronal activity.

Restoration of neurophysiological balance.

Release of endorphins.

Reduction of inflammation.

Improved blood circulation.

Clinical outcomes:

Significant differences in pain scores between weeks (p = 0.022).

Decrease in pain perception, reducing the initial mean from 4.18 to 1.81 (out of 5).

Reference:

Contreras, M., Medina-Ramírez, R., Teruel-Hernandez, E., Vilchez-Barrera, M., Báez-Suárez, A., & Álamo Arce, D. (2023). Rehabilitation in Sleep, Pain, and Bladder Symptoms of NESA Neuromodulation Application in Multiple Sclerosis Patients: A Innovative Treatment. CPQ Medicine Journal, 15(1).

Cognitive ability
+35% in attention, memory, and executive function

Main Scientific Results:

Improvement in cognitive function with NESA Neuromodulation:

35% increase in key cognitive areas such as attention and memory.

Positive implications:

Relevance both in healthy people and in neurodegenerative conditions such as dementia.

Restoration of neurophysiological balance and optimisation of the autonomic nervous system, helping to slow the cognitive decline associated with dementia.

Improved memory, concentration and decision-making ability.

Clinical outcomes:

Significant differences in patients' cognitive function at the four measurement points.

Group NNG showed the best evolution, reaching a score of 30.7 at 7 months.

The NNG group improved by 35% (p < 0.005), while the CG group showed a small worsening.

Reference:

+1,000 scientific posters from health professionals

Every year, over 200 healthcare professionals present scientific posters on non-invasive neuromodulation, showcasing evidence-based clinical outcomes.
This collective knowledge identifies patterns, inspires new therapeutic strategies and guides future clinical trials.
Doctors, physiotherapists, psychologists and other specialists come together with a common purpose: to improve their patients’ quality of life.