Mental Health
MENTAL HEALTH AND THE AUTONOMIC NERVOUS SYSTEM
NESA XSIGNAL® relieves symptoms of anxiety and stress, improving brain communication and restoring neurochemical balance for lasting well-being.







Our advanced technology enables modulation of the autonomic nervous system, offering an effective solution for mental health and chronic symptoms.
NESA XSIGNAL® allows:
- Relief of chronic corticalized pain
- Improve sleep quality
- Regulating
- Reduce stress and anxiety by lowering cortisol levels.
- Improving concentration and increasing alpha waves
- Reducing hostility
Optimise neurophysiological health for holistic wellbeing.

Stress and Anxiety
Our neuromodulation regulates the autonomic nervous system and the HPA axis, reducing sympathetic hyperactivity and cortisol levels. This enhances physiological resilience to stress and attenuates the clinical manifestations of anxiety
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Restorative Sleep
It promotes parasympathetic activation during rest, optimising both REM and non-REM phases. The result is deep, restorative sleep with cognitive and emotional benefits.

Dysautonomies
By restoring autonomic homeostasis, XSIGNAL® reduces hypersensitivity of the nervous system. This relieves symptoms such as fatigue, dizziness or palpitations, significantly improving the patient's quality of life.
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Improve concentration
It balances sympathetic-parasympathetic activity, stabilising alertness without overexcitement. It thus enhances mental clarity, sustained attention and cognitive performance.
Global Trust in NESA®
More than 1,000 clinics, and over 50 hospitals and universities worldwide rely on our technology to optimise rehabilitation treatments and enhance patients’ quality of life.










































PASSIVE NEUROMODULATION OF THE AUTONOMIC NERVOUS SYSTEM IN CLINICAL SETTINGS.
NESA® medical technology standardises passive stimulation protocols, optimising precision and multi-therapy capacity.
THERAPEUTIC SYNERGY: MANUAL TREATMENTS, EXERCISE AND NESA®.
Optimises the autonomic nervous system and boosts recovery in a single treatment.
"After 25 years of professional experience, I felt that I was missing a key tool to enhance my treatments. With NESA, I have found that missing piece which regulates the autonomic nervous system, allowing for a holistic approach that addresses the mental, emotional, and physiological aspects of patients."
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"NESA non-invasive neuromodulation shows promising results in the treatment of anxiety, depression, and sleep disorders. As a psychiatrist, what I value most is that it has no side effects and causes no pain, making it a safe and effective option for improving both mental and physical health."
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"Many of my patients experience difficulty sleeping, which negatively impacts their emotional state and daily functioning. With NESA, patients report improvements in sleep quality, leading to a more balanced emotional state and an overall better quality of life."
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"At our clinic, we have observed that many patients struggle with sleep issues. With NESA technology, we have seen significant improvements in both sleep quality and pain reduction, especially in cases like trigeminal neuralgia, where patients have reported waking up pain-free after years."
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"NESA directly impacts the body, helping to modulate essential functions such as sleep disorders and anxiety, which significantly improves patients' quality of life. This technology addresses the mind-body connection in a holistic manner."
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"One particularly remarkable case is that of a child with autism who initially made no eye contact. Since commencing NESA treatment, he now seeks eye contact, approaches me, and asks questions directly while maintaining eye contact. His vocabulary has also expanded significantly. The progress my patients have made, which would typically take years to achieve without this device, has been notably accelerated."
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"At the NIPACE Foundation, we have been working with NESA for more than five years in the rehabilitation of children with cerebral palsy. We have observed remarkable improvements in urinary control, sleep quality, attention, and a reduction in epileptic seizures."
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"NESA is a technology that can greatly improve the quality of life for older adults, particularly those suffering from anxiety, sleep disturbances, and chronic pain. Even small improvements in these areas can make a significant difference to their daily well-being."
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"One notable case involves a patient with fibromyalgia for more than 17 years, who experienced poor sleep quality and constant pain. After approximately three months of regular NESA sessions, she managed to significantly improve her sleep and reduce pain levels."
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"Fibromyalgia is associated with central sensitisation, a condition where the nervous system becomes overactive and dysregulated. Through NESA, we assist patients in regulating their nervous system, improving overall well-being and reducing chronic symptoms."
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"To address chronic stress and restore the body's balance, it is essential to consider the role of the vagus nerve and the autonomic nervous system. NESA helps individuals regain their ability to self-regulate and find relief from the effects of fibromyalgia."
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Explore more than 800 testimonials from healthcare professionals.
Would you like more information about XSIGNAL® technology in mental health?
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