Our top priority


We allocate most of our human, logistical and economic resources to research, development and innovation (R + D + i)

Since NESA WORLD® was founded, the ultimate obsession has been to certify and endorse technology as a medical device under the 93/42/CEE Medical devices directive, rely on notified bodies and comply with ISO13485 for health technology.

Develop academic agreements and development of clinical and theoretical research with universities, promote randomized clinical trials with independent hospital entities; and finally, have the best neurophysiologists, doctors, physiotherapists and engineers to promote the development and innovation of non-invasive neuromodulation technology, which does not stop developing and is constantly evolving.

And we believe that as of today in the year 2022, it is only the beginning. 



The investigation of the functioning of NESA® microcurrents and their implication in the entire nervous system is and will always be our banner and pillar of our existence. 

Dozens of people are currently working at a national level to give credit to the different observable clinical applications and to understand in greater depth their physiological implications. 

We coordinate public and private institutions so that all of them work in an integral way, bringing together different small work groups to increase efficiency, supporting them with the logistical resources that each study requires. 

For more information on the technology and to know more about the notified bodies you can go to the  frequently asked questions area (FAQS) in NESA® Technology.

Collaborating universities in R + D + i

Currently NESA WORLD® has four research laboratories in four different universities, for the investigation of electrophysiology and clinical implications of NESA® microcurrents.


Collaborating Institutions in Trials
clinical and research papers.

Multiple clinical trials are coordinated from the universities in collaboration with the research team of different institutions of recognized prestige throughout the national and international territory.


The vegetative nervous system is the focus of the investigation.

In the laboratories of the different universities, different clinical research projects are proposed in the fields of medicine, physiotherapy and psychology/psychiatry.

Universities promote their own undergraduate or postgraduate research projects, with the aim of subsequently publishing them in scientific journals in collaboration with other clinical entities: such as hospitals, foundations, medical centers, research hubs, etc.

The different laboratories are logistically supported to be able to address the research projects proposed or the clinical trials approved by the Spanish agency for medicines and health technologies.


Most of the investigations that are carried out are clinical in nature, however researchers use the most innovative feedback technology for biological indicators. From technology for basic inrush physics through electromyography, oscilloscopes, impedance meters, and validated tests; to the deepest biological levels of the basic sciences, such as electroencephalography, actigraphy, sweat meters, electrocardiograms, high-resolution ultrasound and analysis of biomarkers in blood and salivary. 

The objective in the coming years is to demonstrate the theoretical models of the clinical effects that are seen on a day-to-day basis through scientific evidence in areas as important as sleep quality, stress and chronic cortical pain, among others.


A journey of a thousand miles begins with a single step. "Lao Tse"

Research carried out in the 70s in Japan for more than 20 years on the bioelectrical behavior of the human peripheral and autonomic nervous system was based on trial and error; inserting needles on the dermis and finishing at the end emitting and coordinating impulses of low intensity and frequency.

All the research work was resumed from Spain, carrying out clinical trials and private research work on the clinical implications in the autonomic nervous system, recording values of EEG, ECG, actigraphy, biological markers, sport neuroefficiency, recovery from fatigue, assessment of sleep phases, stress markers of cortisol and amylase, biomechanical recovery in whiplash, and clinical cases of chronic and neuropathic pain.


In this section you will find all the works completed by the national and international research team of non-invasive neuromodulation of topological application NESA®. 

Keywords: neuromodulation; Non-invasive neuromodulation; Microcurrents; Autonomous Nerve System;  ANDelectrotherapy; Physiotherapy Modalities  

published studies 

Rico, P., & Aranguren, P. (2016). Superficial neurostimulation application, alpha rhythm and clinical effects. European Psychiatry, 33, S232. https://doi.org/10.1016/j.eurpsy.2016.01.578 

Molina, F., Medina-Ramírez, R., Báez, A. Álamo-Arce, DD. 2020. Successful recovery from a Complex Regional Syndrome through neuromodulation electrotherapy of the Autonomous Nervous System. In J. Chaler Vilasecade of the president of the congress. 58th SERMEF Congress. Majorca, Spain. 

Báez-Suárez, A., Pestana-Miranda, R. Álamo-Arce, D. Martín-Castillo, E., Medina-Ramírez, R. 2020. Effectiveness of non-invasive neuromodulation in children with neurodevelopmental disorders to improve constipation and sleep quality. In SPRM Congress 2020. Belgrade, Serbia.  

Medina-Ramirez, RI., Molina, F., Medina-Ramirez, R., Baez, A. Alamo-Arce. NESA technology. A revolutionary new treatment in physiotherapy. Macaronesian Researcher`s night. In Horizon 2020 Congress. 2020. Las Palmas, Spain. 

Lledó-Amat, M., ancho-Francés, A., Medina-Ramírez, & Álamo-Arce, D. (2021). Treatment of trigeminal neuralgia with non-invasive NESA Neuromodulation: About a case. National Congress of Physiotherapy of the UMH, Spain. 

Lledó-Amat, M., Medina-Ramírez, R., Álamo-Arce, & Arteaga-Ortiz, R. (2021). Effects of non-invasive NESA Neuromodulation in the treatment of stroke sequelae: About a case. National Congress of Physiotherapy of the UMH, Spain.  

Contreras, M., & Medina-Ramirez, RI (2021). Clinical case of applied superficial neuromodulation (NESA) in patients with Multiple Sclerosis. National Physiotherapy Congress UMH, Spain.  

Medina-Ramírez, R., Molina-Cedrés, F., Báez-Suárez, A., & Álamo-Arce, D. (2021). Nesa Noninvasive Neuromodulation; A New Frontier of Treatment of the Autonomous Nervous System in Physiotherapy. 4. https://www.cientperiodique.com/article/CPQOS/5/4/97 

Last update 12/2021. 

Internal research work carried out and not published:  

1st “Efficacy of treatment with NESA Xsignal® electrostimulator in patients with post-traumatic neck pain” Institution: Servicio de Rehabilitación ACTIVA Mutua Madrid Barcelona-Córdoba. 

Summary: 21 patients with the diagnosis of whiplash (classification of grade I-II cervical injury,  following the Foreman and Croft Classification). Said evaluation has been carried out with the biomechanical analysis system  “Biomek” (Movement analysis is performed using three-dimensional videophotogrammetry - motion capture  

using several infrared light-emitting cameras) at the start of protocolized rehabilitation treatment and after 14 days.  The physiotherapy protocol consists of the application of an electrostimulator (NESA XSIGNAL®) combined with exercise  active for 14 days in patients diagnosed with post-traumatic neck pain as a result of a traffic accident  roam. Neck pain and disability questionnaires were also administered at the beginning and after 14 days. 

Results: Good correlation between the reduction of cervical mobility restriction and the manifestation of pain  and disability in 14 days. Statistically analyzed the mobility data (initial assessment vs. evolutionary control)  there is evidence of a significant increase in mobility in the 4 movements: flexion, extension, lateral flexion and  rotation. In relation to the values of the questionnaires, a decrease in pain and cervical disability was obtained.  with respect to the initial values. 

Conclusions: In our study, the usefulness of the biomechanical test to determine the degree of  cervical involvement and monitor the rehabilitation treatment in order to establish the protocols and apply the  novel physical procedures.

2º “Qualitative study of effectiveness, safety and Functioning of the NESA xsignal  device”. Institution: Hospital Quiron Sevilla. 

Summary: 10 patients with relative homogeneity in symptoms were evaluated, as well as  as anthropometric variables. Clinical results were recorded in all cases.  relevant to pain relief. In most of the recorded cases, said  improvement was reported before the fifth intervention session with the NXsignal device  ®.  

3º “Evaluation of the impact on cognitive performance and response parameters  inflammation in relation to high intensity exercise in athletes with a high level of  training (CrossFit ®) by the application of superficial neurostimulation”. Institution: Sant Cugat High Performance Center.  

Summary: Pilot study in which athletes are intervened for 3 months  CrossFit ® practitioners. In the first phase, a work session is established  resistance force standard. The initial sample was 20 individuals of age (21-35  years), who underwent a medical examination, with blood analysis and test of  maximum effort, to rule out inflammatory pathology, discriminate the risk  cardiovascular and characterize level of aerobic physical condition. After the first  30 minutes of training, a new blood extraction was carried out, which will be repeated at  2 hours and 30 minutes after the end of the exercise.  

On the other hand, after finishing the treatment with NESA Xsignal® (90 minutes post  training), the battery of neurocognitive tests that were developed  during the first medical visit and, in relation to strength tests, 10 minutes after  Once the exercise was finished, fatigue tests were carried out, similar to the previous phase of training since  2 hours and 10 minutes (after blood extraction and post intervention with NESA  Xsignal®).  


– The sample was homogeneous. 

– There is a tendency to better recover the group with NESA Xsignal®, which in turn loses  less speed in the immediate post-exercise. 

– The group intervened with the device showed less presence of response  inflammatory (cytokine level). 

– Both groups improved neurocognitive response. The NESA Xsignal® Group  presented a tendency to improve the correct answers in the tests. 

4º «Comparative study of the frontal EGG activity after superficial  neuro-stimulation application, mindfulness and other attentional  techniques.» YoInstitution: University of Alcalá de Henares.  

Subsequently, the same authors designed a study with onektivop, with the aim of  to compare the electrical changes observed after the use of neuromodulation did not  NESA with other mental concentration techniques: Mindfulness (mental attention  without judgment) and a technique based on the emission of a sound. application was used  

NESA microcurrents and was evaluated through digital Encephalogram; Faraday cage.  

Results Mindfulness and SNSA techniques show similarities with respect to the  frequency of the alpha rhythm in the frontal regions (Figures 1 and 2) compared to a  technology of different mental concentration nique (figure 3). However, they need  scalable studies to determine more generalizable results.  

5th “Effectiveness of NESA non-invasive neuromodulation in quality improvement  of sleep and well-being in soccer players; viability study" 

Institution: Alfonso X el Sabio University, Madrid. Spain  

Objective: Verify the effectiveness of the application of non-invasive neuromodulation  NESA on improving the quality of sleep and well-being of soccer players in a  professional team.  

o Determine improvement in sleep quality 

o Assess changes in cortisol concentrations related to sleep and  stress. o Check the feasibility of the study for a subsequent clinical trial  

Type of study: Final Degree Project. Prospective feasibility study of  intervention in two groups of professional soccer athletes (intervention and  placebo).  

Subjects: Healthy soccer players without previous injuries. 

Intervention: 10 sessions, 2 times a week. Applying a core protocol  combining P1, P7, P5. Q4 and Q8.  

Results: After analyzing the results, a significant difference was obtained for the improvement  of sleep quality (pvalue= 0.041) post intervention in the experimental group. Y  although no differences were obtained for cortisol levels, a  significant Pearson correlation (pvalue= 0.009) between the decrease in cortisol post  treatment and improvement of sleep quality.


Clinical trials, preliminary studies, observational studies, Doctoral Theses, Final Degree and Master's Degree Projects

Clinical research is our highest priority, all research is centralized through the collaborating Universities, so that they work in synergy with the hospitals and clinics that carry out the research independently.

Currently our ongoing clinical trials are aimed at investigating the implications of NESA® microcurrents in:

  • Acceleration in the recovery of musculoskeletal and post-operative injuries
  • Improvement of cardiac variability and reduction of stress
  • Reduction of chronic and neuropathic pain
  • Decreased symptoms of overactive bladder
  • Improvement of peristalsis and sleep quality in children with cerebral palsy (PCI)
  • Improved sleep quality
  • Recovery from the aftermath post Covid-19
  • Rehabilitation and reduction of spasticity in neurological patients
  • Reduction of stress and anxiety in students.

Among other projects that are being approved by the drug agency and based on our logistics absorption capacity.


Here are some videos briefly explaining some of the ongoing clinical trials and research with NESA® non-invasive neuromodulation. 

Research work

Efficacy of NESA® non-invasive neuromodulation in the neuroefficiency of basketball players. Innovation Hub FC Barcelona. 2022

clinical trial

Clinical Trial / Chronic pain in the regional syndrome Complex I. Hospital MAZ Zaragoza and the ULPGC.

Research work

Multiple Sclerosis by Aeequs Clinic, ABDMEN and ULPGC. Feat. NESA WORLD® - 2021 - 2022

clinical trial

Recovery of the Anterior Cruciate Ligament with NESA® microcurrents - Clinica Sant Josep Manresa: 2021-2022

clinical trial

Peristalsis and sleep in children with cerebral palsy with NESA® microcurrents - Hospital San Juan De Dios de Las Palmas: 2021-2022

clinical trial

Post-operative knee prosthesis with NESA® microcurrents - Hospital San Juan De Dios de Tenerife: 2021-2022

clinical trial

Overactive Bladder with NESA® microcurrents. - HOSPITEN Tenerife and Maternal and Child Hospital Gran Canaria: 2021-2022

clinical trial

Complex regional syndrome type I (Südeck) with NESA® microcurrents. - MAZ Hospital in Zaragoza: 2021-2022

clinical trial

How NESA® microcurrents affect the recovery of tendinopathies. - AKRO Clinic


Establish common objectives with universities to develop research

Our basis for success is that clinical entities can propose their own projects to the different leading institutions in neuromodulation research of the autonomic nervous system.

Have a common scientific objective, and with the possibility of receiving help
logistics and advice in the process of carrying out the investigation. 

We develop a common objective, and we encourage logistical and advisory help in the process of carrying out the investigation. Procedures such as the management of the ethics committee, procedures with the drug agency, registration of clinical trials, preparation of research protocols, statistical analysis, etc.

In this section we propose to all those people who have the NESA® non-invasive neuromodulation technology the way to propose a research in collaboration with the research teams in clinical implications. 

This form is also open for institutions with a long scientific history that would like to collaborate in the scientific field with the various universities that coordinate the studies of NESA® microcurrents. 

* The response to this form is a few months. 

* This form will go to the NESA® microcurrent research coordination team of the University of Las Palmas de Gran Canaria of Health Sciences. 



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