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Non-invasive microcurrent therapy to rebalance the autonomic nervous system.

NESA XSIGNAL

NESA XSIGNAL® TENS – Advanced Non-invasive Neuromodulation

NESA XSIGNAL® administers low-frequency microcurrents via 24 emitter electrodes positioned on peripheral nerves, achieving comprehensive regulation of the autonomic nervous system and enabling precise, effective modulation of autonomic activity.

The device delivers up to 19,000 bioelectric pulses per minute at frequencies of 1–14 Hz, providing gentle, painless, and safe stimulation that supports homeostasis and facilitates functional recovery. Health registrations are at an advanced stage in Brazil, Chile, the USA, Taiwan, Malaysia, Egypt, Saudi Arabia, Kuwait, Jordan, Kosovo, India, and Nepal.

Technical specifications:

Input power supply:

  • Power supply (supplied by the manufacturer)
  • 110-240 Vac 50-60 Hz
  • 5V cc / 2 A

Signal output:

  • Voltage / current: ± 10 V / 0.5 mA per channel.
  • Frequency range: 1 Hz to 14 Hz

Device:

  • Enclosure: Painted steel.
  • Dimensions: 157.5 mm (L) x 110 mm (w) x 45.5 mm (h)
  • Weight: approx. 1.2 kg
  • Transmitting electrodes: 24
  • Directional electrode: 1
  • Battery: 8,500 mA/h, (Autonomy 8 hours)
  • IP02

Device certifications and regulations complied with:

  • Certified in accordance with Medical Device Directive MDD 93/42/EEC (Class IIa)
  • European Directive 2012/19/EU. On waste electrical and electronic
    equipment (WEE)
  • European Directive 2011/65/EU.
    Restrictions on the use of certain hazardous substances (RoHS)

Health registration

  • Registered as a medical device in the following countries: Canada, Mexico, Argentina, Colombia,
    Costa Rica, Peru, United Kingdom, Switzerland and United Arab Emirates.
  • Health registrations in advanced stages of processing in: Brazil, United States,
    Taiwan, Malaysia, Egypt, Saudi Arabia, Kuwait, Jordan, Kosovo, India, and
    Nepal

Want more details?

Contact a specialist.

What's included in the NESA XSIGNAL® TENS:

MAIN EQUIPMENT

  • NESA XSIGNAL® TENS medical devic
  • NESA XSIGNAL® Timer

CABLES AND CONNECTIVITY

  • CEXT-N extension cables (4 pcs.: blue, red, green and yellow)
  • CONTACT-NC connection cables (4 pcs.: blue, red, green and yellow)
  • Addressing cable GDCN (1 pc.)
  • CONTACT-NC Cable Disconnecting Pick

POWER AND ENERGY

  • Power supply with international adapters

TRANSPORT AND PROTECTION

  • Heavy duty suitcase
  • Transport rucksack

DIAGNOSIS AND MONITORING

  • Wecardio portable electrocardiograph
  • Android Tablet with pre-installed ECG app + installation videos

FURNITURE AND STANDS

  • Adapted furniture with castors

  • Tablet holder

CONSUMABLES AND PATIENT COMFORT

  • NESAKITS (gloves and anklets, sizes S-M-L; includes electrodes, user's guide and
    treatment guide)

* We recommend individual use per patient for greater hygiene and comfort.

  • NESA CLINICS® Towels


  • NESA CLINICS® Blanket

TRAINING INCLUDED

  • Printed instruction manual
  • Non-invasive neuromodulation training kit

CLINIC KIT (only for authorised centres)

  • Personalised circle of authorised centres
  • Neural synapse vinyl (120 cm × 180 cm, personalised)
  • NESA® LED backlit logo
  • Pack of 250 promotional leaflets

  • Roll-up – Autonomic nervous system

DIGITAL ACADEMIC PRODUCT INCLUDED

  • Introductory Campus (8 languages, +6 h of training)
  • Clinical Guidelines Campus (+30 h of contents, cases and protocols)

DIGITAL KIT (DEPENDING ON PURCHASE OPTIONS)

  • Course “Expert in non-invasive Neuromodulation NESA®”.
  • Permanent access to the NESA online campus
  • Ongoing clinical counselling with the NESA team
  • 1 year additional XSIGNAL warranty
  • Digital communication pack (audiovisual content and customised videos for
    social networks and other digital platforms).
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NESA CLINICS - Autonomic System Optimisation

“The autonomic nervous system is the axis of homeostasis.” — Guyton & Hall

Integrate a NESA Clinics Unit in your centre

You don’t need a dedicated space to achieve results with

NESA XSIGNAL® non-invasive neuromodulation.

Nevertheless, having a NESA Clinics Unit elevates the patient experience
by providing an optimised, comfortable environment

that meets NESAWORLD clinical standards.

Do you want to differentiate your centre and enhance the therapeutic benefits?

Find out how to create your NESA Clinics Unit here.
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ACQUIRE NESA XSIGNAL®

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NESA WORLD

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EASO Building, local 1,
20018 Donostia/San Sebastián
(Guipuzcoa)

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REFERENCES PAPERS

  1. García F, Fernández D, Vázquez-Guerrero J, et al. (2022) Recovery of the physiological status in professional basketball players using NESA neuromodulation treatment during different types of microcycles in season: A preliminary randomized clinical trial.Frontiers in Physiology. 2022;13.https://www.frontiersin.org/articles/10.3389/fphys.2022.1032020
  2. Medina-Ramírez, R., Molina-Cedrés, F., Báez-Suárez, A., & Álamo-Arce, D. (2021). Nesa Non-Invasive Neuromodulation; A New Frontier of Treatment of the Autonomous Nervous System in Physiotherapy. 4.DOI: https://www.cientperiodique.com/article/CPQOS/5/4/97

  3. Teruel-Hernández, E., López-Pina, J. A., Souto-Camba, S., Báez-Suárez, A., Medina-Ramírez, R., & Gómez-Conesa, A. (2023). Improving sleep quality, daytime sleepiness, and cognitive function in patients with dementia by therapeutic exercise and NESA neuromodulation: A multicenter clinical trial. International Journal of Environmental Research and Public Health, 20(21), 7027. https://doi.org/10.3390/ijerph20217027

  4. Báez-Suárez, A., Padrón-Rodríguez, I., Castellano-Moreno, E., González-González, E., Quintana-Montesdeoca, M. P., & Medina-Ramirez, R. I. (2023). Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation. BMC Pediatrics, 23(1), 465. https://doi.org/10.1186/s12887-023-04307-4

  5. Contreras, M., Medina-Ramírez, R., Teruel-Hernandez, E., Vilchez-Barrera, M., Báez-Suárez, A., & Álamo Arce, David. (2023). Rehabilitation in Sleep, Pain, and Bladder Symptoms of NESA Neuromodulation Application in Multiple Sclerosis Patients: A Innovative Treatment. CPQ Medicine Journal, 15(1). https://www.cientperiodique.com/article/CPQME-15-1-439.pdf
  6. Medina-Ramírez, R., Mallol Soler, M., García, F., Pla, F., Báez-Suárez, A., Teruel Hernández, E., Álamo-Arce, D. D., & Quintana-Montesdeoca, M. d. P. (2024). Effects in sleep and recovery processes of NESA neuromodulation technique application in young professional basketball players: A preliminary study. Stresses, 4(2), 238-250. https://doi.org/10.3390/stresses4020014

  7. Bonilla-Eizaguirre, M., Martín, M., Hernández-Pérez, A., Vílchez-Barrera, M., Medina-Ramírez, R., & Báez-Suárez, A. (2024). Efficacy of NESA non-invasive neuromodulation in patients with post-traumatic cervicalgia. International Journal of Research and Scientific Innovation (IJRSI), 11(10), 474. https://doi.org/10.51244/IJRSI

  8. Vega-Delgado, N., García-Rodríguez, I., Saldanha, L., Báez-Suárez, A., Vílchez-Barrera, M., Álamo-Arce, D., Hernández-Pérez, A., & Medina-Ramírez, R. (2024). New frontier in sleep disorders: The rising of an innovative non-invasive neuromodulation treatment. International Journal of Research and Scientific Innovation (IJRSI), 11(15), 49. https://doi.org/10.51244/IJRSI.2024.11150049P

  9. Báez-Suárez, A., Báez-Suárez, V., Saldanha, L., Vílchez-Barrera, M., Hernández-Pérez, A., & Medina-Ramírez, R. (2025). Improving Sleep Quality and Well-Being in Institutionalized Older Adults: The Potential of NESA Non-Invasive Neuromodulation Treatment. Geriatrics, 10(1), 4. https://doi.org/10.3390/geriatrics10010004

  10. VASCULAR Front. Physiol Acute sonographic changes in common carotid artery after NESA neuromodulation intervention in healthy adults: a randomized controlled clinical trial doi: 10.3389/fphys.2025.1526236
    https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1526236/abstract

  11. PAIN Azevedo, N., & Medina-Ramírez, R. (2025). Pain and the autonomic nervous system: The role of non-invasive neuromodulation with NESA microcurrents. Frontiers in Pain Research, 6, Article 1410808. https://doi.org/10.3389/fpain.2025.1410808

CONFERENCES

  1. Molina, F., Medina-Ramírez, R., Báez, A. Álamo-Arce, DD. (2020). Recuperación exitosa de un Síndrome Regional Complejo a través de la electroterapia de neuromodulación del Sistema Nervioso Autónomo. 58o Congreso SERMEF. Mallorca, España.http://hdl.handle.net/10553/114084

  2. Medina-Ramírez. (2021). ¿Los deportistas profesionales tienen una óptima calidad del sueño?Aprender a dormir, una asignatura pendiente. XXIX Reunión Anual de la Sociedad Española del Sueño, España.

  3. Medina-Ramírez, RI., Molina, F., Medina-Ramírez, R., Báez, A. Álamo-Arce. Tecnología NESA. Un nuevo tratamiento revolucionario en fisioterapia. Macaronesian Researcher`s night. In Horizonte 2020 Congress. 2020. Las Palmas, Spain.

  4. Lledó-Amat, M., Medina-Ramírez, R., Álamo-Arce, & Arteaga-Ortiz, R. (2021). Efectos de la Neuromodulación no invasiva NESA en el tratamiento de secuelas de Ictus: A propósito de un caso. Congreso Nacional de Fisioterapia de la UMH, España.

  5. Lledó-Amat, M., ancho-Francés, A., Medina-Ramírez, & Álamo-Arce, D. (2021). Tratamiento de la neuralgia del trigémino con Neuromodulación no invasiva NESA: A propósito de un caso. Congreso Nacional de Fisioterapia de la UMH, España.

  6. Medina-Ramírez, R., & Roman, T. (2021). Efectos de la Neuromodulación no invasiva NESA en el tono muscular, el dolor y el sueño, en pacientes bruxistas.Aprender a dormir, una asignatura pendiente. XXI reunión Anual de la Sociedad Española del Sueño, España.

  7. Contreras, M., & Medina-Ramírez, R. I. (2021). Caso clínico de neuromodulación superficial aplicada (NESA) en pacientes con Esclerosis Múltiple. Congreso de fisioterapia nacional UMH, España

  8. Medina-Ramírez, R., Molina-Cedrés, F., & Moreno, A. (2022). Potenciando la fisioterapia invasiva a través del sistema nervioso autónomo. I JORNADA PRESENCIAL Fisioterapia invasiva. Barceona, Spain.

  9. Cano-Uceda, A. Aparicio-Montero, P. Medina-ramírez, R. (2023) Effectiveness of non-invasive neuromodulation in improving sleep quality and stress in physiotherapy students. Multicenter study. In SPRM Congress 2023. Colombia.

  10. Molina-Cedrés, F., González, M., & Medina-Ramírez, R. (2022). Combining physiotherapy techniques: Treatment of plantar fasciitis with NESA neuromodulation and electrolysis. The International Society for Physical Rehabilitation Medicine Conference. The International Society for Physical Rehabilitation Medicine, Lisbon, Portugal.

  11. Contreras, M., Medina-Ramírez, R., & Molina-Cedrés. (2022). Nesa Non-invasive neuromodulation; a chance to approach Sclerosis Multiple symptoms. The International Society for Physical Rehabilitation Medicine Conference. The International Society for Physical Rehabilitation Medicine, Lisbon, Portugal.

  12. Báez-Suárez, A., Medina-Ramírez, R., Molina-Cedrés, Padrón, I., Montesdeoca, M. del P., Castellano, E., & González, E. (2022). Can microcurrents help children with neurodevelopmental disorders with their defecation and sleep quality problems? The International Society for Physical Rehabilitation Medicine Conference. The International Society for Physical Rehabilitation Medicine, Lisbon, Portugal.

  13. Ruíz-lópez, K., González, M., & Medina-Ramírez, R. (2023). NESA Neuromodulation in pelvic floor and uroginecology. I NESAevent Internacional Conference. I NESAevent Internacional Conference, Madrid, Spain.

  14. Medina-Ramírez, R., Molina-Cedrés, F., Báez-Suárez, A., Álamo Arce, D., & Mallol-Soler, M. (2022). Improving sleep quality: The new frontier of physical therapy neuromodulation of the autonomic nervous system. Congreso Internacional de Fisioterapia de Cataluña. Congreso Internacional de Fisioterapia de Cataluña, Barcelona, Spain.

  15. Báez-Suárez, A., Pestana-Miranda,R. Álamo-Arce, D. Martín-Castillo, E., Medina-Ramírez, R.(2020). Effectiveness of non-invasive neuromodulation in children with neurodevelopmental disorders to improve constipation and sleep quality. In SPRM Congress. Belgrade, Serbia.

  16. Zamorano, E., & Medina-Ramírez, R. (2022). Face to Face. Neuromodulación percutánea versus no invasiva (sistemas inductivos de alta intensidad y NESA). V Congreso Internacional de Fisioterapia Invasiva. V Congreso Internacional de Fisioterapia Invasiva, Madrid, Spain.

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